So we have established at this point that there is a hefty amount of comedy in games.
Its just that comedic aspects of the games are involved in the storylines or in the characters and how they react rather than in the actuall gameplay. I'm... relucant to bring up the subect of "Leisure Suit Larry" which for all of its vulargity was a game based on comedy. Apparetnly they tried a remake recently that failed miserably, despite efforts at making a funny game.
The things about games are, I think... well its like Bungie's montra for making games. Make five seconds of something fun, then repeat endlessly. The same might work for fun, but not nessecarily for comedy. A joke gets stale after a while so making a funny game is very difficult because the humor must be mixed up rather constanly. You can't have the same jokes playing over and over like you can have the same enemies flooding the screen.
Just my quick thoughts!